Antiseptic.



' mm STATES PATENT OFFIC PROSPER J AUG-NSTE MAIGNEN, OF PHILADELPHIA, PENNSYLVANIA;

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. Specification ofLetters Patent.

No Drawing Continuation of applicationserial imisa'saa filed March 29, 1909. This ,appli cation filed September 18 1913. Serial Ii'o.790, 399.

To all whom it may concern I Be it known that I, Pnosrnn JEAN AUeUs'rE MAIGNEN, a citizen of France, and resident of Philadelphia, in the State of Pennsyl vania, have invented a certain new and useful Improvement in Antiseptics, whereof the following is a specification.

' carbonate, aluminum sulfate and boric acid,

' limit and control the action of said evolved,

It is the object of my invention to provide means for destroying bacteria inhabiting living tissue, without injuring the latter, by progressively evolving SOdlllIIl' hydroxid contiguous to said tissue, fromand in amoist mixture of calcium hydroxid, sodium which, with the products of their reaction,

sodium hydroxid; whereby albu'minous proteid bacterial substance and purulent ,matter are dissolved without deleterious effect upon contiguous healthy tissue; Said process is the subject matter of my eopending application Serial 7 7 8,428 filed July 11, 1913 which application is'a continuation; the claiins of this application being limited to a composition of matter used in said process, as hereinafter described.

The means. for progressively evolving sodium hydroxid, in accordance with my invention, include a primarily dry powdered mixture of a calcium hydroxid, sodium carbonate, boric acid and aluminum sulfate, which maybe mixed in various proportions. Said substances are capable ofexist-ing,-in dry mixture, without chemical re-.

action upon each other,but in the presence of w and alum.

liz'ed by the full strength mixture it may be desirable to fill the cav1ty with a dusting powder of less active power, as a dressing,

in which .case the original mixturemay be i diluted with an equal weight of calcium carbonate or other inert substance, which has 4 of egg,- 1s a division of my application Serial 486,334, filed'March 29,1909, of which this no other effect in the premises than to act as preparing my 'remedy for dental purposes I prefer to dilute the mixture with three times its weight of calcium carbonate or other such inert substances.

I have discovered by microscopical investigationthat said remedy has the property of Patented 11a. 3,1914. I

a vehicle and diluent for the remedy. In

separating the albuininous '(proteid) matten, from the nuclei of the microorgamsms; :Ihealbuminous matter being thus-separated it can'be. seen with the microscope that the nucleibreak away into separate units, which, bacteriological, tests show to be absolutely lifeless and incapable of growth or reproduction. I have found by experimentation upon myself and others that said remedy has a similar disintegrating efi'ect uponv the broken down tissues, and that it transforms the individual pus cells of a wound into a plastic viscous substance resembling white which leaves the wound easily and completely." I-;have also found that said remedy has absolutely no deleterious eifect upon healthy tissues whether they are in the immediate proximity ofthe' injured part or away from it. On the contrary ithas a distinctively beneficial bio-.chemical or tonic influence on the healthy tissues which surround the injured part. Therefore, said remedy may be applied with particular advantage wherever there is a lesion exposed .to bacterial infection or already infected.

Said mixture may bea'pplied to the injured tissues, eitheras a dry powder or as an aqueous-mixture at various degrees ofdi1ution, in accordance with the location and nature of the injury. For application to the air. passages in the throat, nose' and lungs in cases of pulmonary vphthisis, pneumonia, catarrh and other infections so located that the air. alone canbe used as a vehicle to reachthe injured part, the mixture in the form of dry powder may be diluted by air, in which it is agitated in any convenient mannerv andinhaled. Thus appliedthe fine particles of the mixture settle upon the injured tissues. The moisture from the latter dissolves the soluble part of; the mixture. The nascent products which result from thls' reaction or ionization as well as the suspended residue of theelements themselves combiine-to destroy the-bacteria, and dry up and sterilize the part as above described Saidantiseptic may also be used as anaqueous mixture in half to five per cent. of the active elements, according to the nature, condition and location of the injured tissues. The Weakest aqueous mixture may be employed when dealing With delicate tissues, nasal, labial, conjunctival and other sensitive membranes; the strongest aqueous mixture may be employed for serious injuries suchtas ulcers, abscesses and cancerous growths. The one per cent. aqueous mixture may be considered a normal solution and employed for injuries to the alimentary canal and skin disorders.

I do not desire to limit myself to the precise proportions or methods of application of my remedy above described, as it is obvious that various modifications may be made proportions varying from one-- therein Without departing from the essential calcium hydroxid, aluminum sulfate, sodium carbonate and boric acid.

2. An antiseptic including a mixture of calcium hydroxid, aluminum sulfate, sodium carbonate and bori acid as a dry powder.

In testimony whereof, I have hereunto signed my name at Philadelphia, Pennsyl- Vania, this tenth day of September, 1913.

PROSPER JEAN AUGUSTE MAIGNEN.

Witnesses:

ARTHUR E. PAIGE, ANNA IsRAELvITz. 

